Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan. Center for Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences, Kumamoto, Japan. Department of Laboratory Medicine, Kumamoto University, Kumamoto, Japan. Department of Medical Information Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of General Medicine and Primary Care, Kumamoto University Hospital, Kumamoto, Japan. Nishinihon Hospital, Kumamoto, Japan. Division of Cardiology, Amakusa Medical Center, Amakusa, Japan. Sakanashi Heart Clinic, Aso, Japan. Hirayama Heart Clinic, Kumamoto, Japan. Division of Cardiology, Japan Community Health Care Organization, Hitoyoshi Medical Center, Hitoyoshi, Japan. Division of Cardiology, Shinbeppu Hospital, Beppu, Japan. Department of Cardiovascular Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka, Japan. Department of Cardiology, Kumamoto City Hospital, Kumamoto, Japan. Division of Cardiology, Kumamoto Kenhoku Hospital, Tamana, Japan. Primary Medical Science Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan. Data Intelligence Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan. tsujita@kumamoto-u.ac.jp. Center for Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences, Kumamoto, Japan. tsujita@kumamoto-u.ac.jp.